期刊
MACROMOLECULAR BIOSCIENCE
卷 15, 期 9, 页码 1182-1197出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201500100
关键词
bone; morphogenetic activity; polyphosphate; regenerative medicine; tissue engineering
资金
- ERC [268476 BIOSILICA]
- European Commission [604036, 286059, 268476, 311848]
- International Human Frontier Science Program
The initial mineralization centers during human bone formation onto osteoblasts are composed of CaCO3. Those bioseeds are enzymatically formed via carbonic anhydrase(s) in close association with the cell surface of the osteoblasts. Subsequently, the bicarbonate/carbonate anions are exchanged non-enzymatically by inorganic phosphate [P-i]. One source for the supply of P-i is polyphosphate [polyP] which is a physiological polymer, formed in the osteoblasts as well as in the platelets. The energy-rich acid anhydride bonds within the polyP chain are cleaved by phosphatase(s); during this reaction free-energy might be released that could be re-used, as metabolic fuel, for the maintenance of the steady-state concentrations of the substrates/products during mineralization. Finally it is outlined that polyP, as a morphogenetically active scaffold, is even suitable for 3D cell printing.
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