期刊
MACROMOLECULAR BIOSCIENCE
卷 16, 期 4, 页码 482-495出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201500275
关键词
adhesion; biocompatibility; mechanical properties; polyelectrolytes; tissue engineering
资金
- European Commission [247656]
- Spanish Ministry of Economy (MINECO) [MAT2013-48169-R]
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET, Argentina) [PIP 0602]
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT, Argentina) [PICT-163/08, PICT-2010-2554, PICT-2013-0905]
- Austrian Institute of Technology GmbH (AIT-CONICET Partner Group: Exploratory Research for Advanced Technologies in Supramolecular Materials Science) [4947/11, 3911]
- Universidad Nacional de La Plata (UNLP)
Polyelectrolyte multilayers (PEMs) with different polycation/polyanion pairs are fabricated by the layer-by-layer technique employing synthetic, natural, and both types of polyelectrolytes. The impact of the chemical composition of PEMs on cell adhesion is assessed by studying cell shape, spreading area, focal contacts, and cell proliferation for the A549 cell line. Cells exhibit good adhesion on PEMs containing natural polycations and poly(sodium 4-styrenesulfonate) (PSS) as polyanion, but limited adhesion is observed on PEMs fabricated from both natural polyelectrolytes. PEMs are then assembled, depositing a block of natural polyelectrolytes on top of a stiffer block with PSS as polyanion. Cell adhesion is enhanced on top of the diblock PEMs compared to purely natural PEMs. This fact could be explained by the interdigitation between polyelectrolytes from the two blocks. Diblock PEM assembly provides a simple means to tune cell adhesion on biocompatible PEMs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据