期刊
MACROMOLECULAR BIOSCIENCE
卷 15, 期 9, 页码 1252-1261出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201500043
关键词
antitumor; co-delivery; curcumin; doxorubicin; polymeric micelles
资金
- Specialized Research Fund for the Doctoral Program of Higher Education [20130013120008]
- Youth Foundation of Beijing University of Chinese Medicine [2013-QNJSZX024]
P-gp mediated drug efflux has been recognized as a major obstacle limiting the success of cancer chemotherapy. To overcome this issue, doxorubicin (DOX) and curcumin (Cur; P-gp inhibitor and apoptosis inhibitor) co-encapsulated pegylated polymeric micelles ((DOX+Cur)-PMs) were designed, prepared and characterized to simultaneously deliver chemotherapeutic drug and multidrug resistance (MDR) modulator to tumor sites. The (DOX+Cur)-PMs were spherical nano-size particle, with a loading content of 6.83%, and high colloidal stability. Co-delivery micelles exhibited excellent cytotoxicity by reversing MDR, promoting cellular uptake and enhancing cellular apoptosis in MCF7/Adr cells. The tumor growth inhibitory effect of (DOX+Cur)-PMs in 4T1-bearing mice was more effective compared with the combination solution of DOX and Cur and even DOX-PMs. In conclusion, simultaneous delivery of DOX and Cur by (DOX+Cur)-PMs has been demonstrated to be a promising approach for overcoming MDR and improving antitumor efficacy.
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