期刊
MACROMOLECULAR BIOSCIENCE
卷 16, 期 1, 页码 160-167出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201500235
关键词
Ag-Au alloy nanoclusters; fluorescent gene carrier; gene transfection; quantum yield
资金
- National Natural Science Foundation of China [51222307, 2147410451390484, 51233004, 51303173, 51403205]
- Jilin Province Science and Technology Development Program [20130521011JH]
For systemic delivery of gene, gold nanoparticles (GNPs) have been exploited as novel gene carriers because of the excellent characteristics for visible in intracellular trafficking. Herein, a highly fluorescent gene carrier was prepared by conjugating polyethylenimines on Ag-Au alloy nanoclusters. This carrier exhibited remarkable high gene transfection efficiencies and relatively low cytotoxicity toward B16F10, HeLa, and CHO cells. More interestingly, the high fluorescent Ag-Au-PEI conjugates showed high quantum yield of 14.56%, which is much higher than most of the reported gold nanocluster-based quantum dots and Ag-Au-PEI possessed bioimaging capacity both in vitro and in vivo.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据