期刊
MACROMOLECULAR BIOSCIENCE
卷 16, 期 2, 页码 231-241出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201500280
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资金
- National Science Foundation CMMI [1333651]
- DMR [1452257]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1452257] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1333651] Funding Source: National Science Foundation
The combination of antibodies with nanoparticles provides wide-ranging applications in biosensing. While several covalent presentation strategies have been established, there is need for alternative, non-covalent methods to provide a routine for scalable nanomanufacturing. We report the multivalent presentation of the B domain of Staphylococcus aureus protein A (SpAB) on potato virus X (PVX) nanoparticles. Three different synthetic strategies were used to obtain chimeric PVXSpAB filaments. The protein A fragments displayed on the surface of all three PVX chimeras remained fully functional as an immunoabsorbent for antibody capture enabling biosensing. The new biomaterials presented could find applications as diagnostic tools for biomedical or environmental monitoring.
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