Switch-Matrix-Based High-Density Microelectrode Array in CMOS Technology

We report on a CMOS-based microelectrode array (MEA) featuring 11,011 metal electrodes and 126 channels, each of which comprises recording and stimulation electronics, for extracellular bidirectional communication with electrogenic cells, such as neurons or cardiomyocytes. The important features include: (i) high spatial resolution at (sub) cellular level with 3150 electrodes per mm(2) (electrode diameter 7 mu m, electrode pitch 18 mu m); (ii) a reconfigurable routing of the recording sites to the 126 channels; and (iii) low noise levels.