期刊
IEEE ELECTRON DEVICE LETTERS
卷 35, 期 3, 页码 333-335出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/LED.2014.2298397
关键词
AlGaAs/GaAs; HEMT; biosensor
资金
- National Natural Science Foundation of China [21307130, 61106004, 61204012, 61274049, 61376058]
- Beijing Natural Science Foundation [4132070]
- Beijing Nova Program [2010B056]
- NNSF Outstanding Youth Fund [50625205]
Alpha-fetoprotein (AFP) is a typical tumor marker in early diagnosis. Highly specific detection of the AFP was demonstrated using AlGaAs/GaAs high electron mobility transistors (HEMTs). Anti-AFP antibody was immobilized to the Au-coated gate area of the HEMT by a covalent modification method. To avoid any nonspecific binding, the gate was blocked by bovine serum albumin after the reduction of the carbonyl group. A detection limit for the AFP as low as a few picograms/milliliter was achieved, and cross reactivity of the sensor was found negligible, demonstrating its high selectivity. Successful detection with minute quantity of the sample indicates that the sensor has great potential in practical screening for a wide population.
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