期刊
HYPERTENSION RESEARCH
卷 41, 期 11, 页码 965-972出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41440-018-0103-8
关键词
Blood pressure; cardiovascular disease; depression; hypertension; sex
资金
- 21st Century Center of Excellence Project by Japan's Ministry of Education, Culture, Sports, Science and Technology
- Foundation for Development of the Community (Tochigi)
- Omron Healthcare Co., Ltd.
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan [21390247]
- MEXT-Supported Program for the Strategic Research Foundation at Private Universities, 2011-2015 Cooperative Basic and Clinical Research on Circadian Medicine [S1101022]
Depression is associated with mortality in patients with cardiovascular risk factors. The frequency and severity of depression and the association between depression and cardiovascular events have sex-specific and ethnic differences. We conducted this study to evaluate the sex-specific difference in the association between depression and cardiovascular prognosis in patients with cardiovascular risk factors. We enrolled 4025 patients (64.7 +/- 10.9 years, 53% women, 47% men) with cardiovascular risk factors in the Japan Morning Surge-Home Blood Pressure study. Depressive symptoms were assessed using the Beck Depression Inventory (BDI). The follow-up period was 47 +/- 24 months. The primary end points were all-cause mortality and nonfatal cardiovascular events. The BDI scores and the prevalence of depression were significantly higher in women than in men. When a BDI score of 16 was the cutoff, the primary end points in the depression group (n = 217) were significantly higher than those in the nondepression group (n = 1677) among men (adjusted hazard ratio 1.76, 95% confidence interval: 1.17, 2.64; P = 0.007). In women, the primary end points in the depression and nondepression groups were similar when BDI scores of 16, 14, and 10 were the cutoffs. In conclusion, depression defined by a BDI score >= 16 was associated with cardiovascular events in men with cardiovascular risk factors.
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