Serum uric acid is an independent risk factor for cardiovascular disease and mortality in hypertensive patients

The purpose of the study was to investigate the association of serum uric acid (UA) levels in hypertensive patients with the prognosis for cardiovascular disease (CVD) and mortality. This hospital-based cohort study included 669 patients with essential hypertension. A questionnaire was used to identify patients in whom hypertensive complications had occurred, as well as causes of death. The primary end point of this study was new onset of stroke or CVD (new onset of angina pectoris, myocardial infarction or heart failure). We evaluated the baseline characteristics of patients, including UA levels, and assessed whether UA levels could be used to predict stroke and CVD. We also classified subjects into four groups according to the serum UA levels. During a mean follow-up period of 7.1 +/- 0.1 years, 71 strokes, 58 cases of CVD and 64 deaths were recorded. Kaplan-Meier analysis revealed that subjects in the high UA group had a higher frequency of stroke and CVD (P = 0.0120) and total mortality (P = 0.0021). A Cox proportional hazard model determined that, after adjusting for traditional risk factors, serum UA levels were predictive of CVD (relative risk = 1.30; P = 0.0073), stroke and CVD (relative risk = 1.19; P = 0.0141), mortality (relative risk = 1.23; P = 0.0353) and stroke CVD and mortality (relative risk = 1.19; P = 0.0083), but not stroke (P = 0.4268). The significant correlations were particularly marked in women. Serum UA levels may be an independent risk factor for stroke and CVD in patients with essential hypertension, particularly women. Hypertension Research (2012) 35, 1087-1092; doi:10.1038/hr.2012.99; published online 28 June 2012