The Role of Transient Receptor Potential Channels in Metabolic Syndrome

Metabolic syndrome Is correlated with increased cardiovascular risk and characterized by several factors, including visceral obesity, hypertension, Insulin resistance, and dyslipidemia. Several members of a large family of nonselective cation entry channels, e.g., transient receptor potential (TRP) canonical (TRPC), vanillold (TRPV), and melastatin (TRPM) channels, have been associated with the development of cardiovascular diseases. Thus, disruption of TRIP channel expression or function may account for the observed Increased cardiovascular risk in metabolic syndrome patients. TRPV1 regulates adipogenesis and Inflammation in adipose tissues, whereas TRPC3, TRPC5, TRPC6, TRPV1, and TRPM7 are Involved in vasoconstriction and regulation of blood pressure. Other members of the TRIP family are involved in regulation of insulin secretion, lipid composition, and atherosclerosis. Although there is no evidence that a single TRIP channelopathy may be the cause of all metabolic syndrome characteristics, further studies will help to clarify the role of specific TRIP channels involved in the metabolic syndrome. (Hypertens Res 2008; 31: 1989-1995)