期刊
HYPERTENSION IN PREGNANCY
卷 27, 期 1, 页码 1-16出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10641950701826067
关键词
cytokines; lipopolysaccharide; in vitro; whole blood
The pathophysiology of preeclampsia (PET) implicates an inflammatory dysfunction. This study profiled this host response by challenging whole blood with lipopolysaccharide. Multiplex immunoassays determined interleukin (IL)-1 beta IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12(p70), IL-13, IL-17, granulocyte/granulocyte macrophage-colony stimulating factors (G-CSF/GM-SCF), interferon(IFN)-gamma monocyte chemotactic protein (MCP)-1, macrophage inflammatory protein-1 beta and tumor necrosis factor (TNF)-alpha levels. Secretory capacity was expressed in pg/million white cells or monocytes (SEM). PET featured significantly higher IL-1, IL-2, IL-10, IL-13, G-CSF, IFN-gamma MCP-1 and TNF-alpha monocyte secretory capacities (p < 0.05). The PET group exhibited an inflammatory hyper-responsiveness (p < 0.01) which was poorly described by the traditional Th1:Th2 dichotomy.
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