4.7 Article

Flow-Mediated Dilation of the Radial Artery Is Offset by Flow-Induced Reduction in Transmural Pressure

期刊

HYPERTENSION
卷 57, 期 6, 页码 1145-1150

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/HYPERTENSIONAHA.110.163113

关键词

blood flow velocity; blood pressure; nitric oxide; vasodilation; vascular endothelium-dependent relaxation

资金

  1. British Heart Foundation [PG/05/138/20014]
  2. Department of Health via the National Institute for Health Research comprehensive Biomedical Research Centre
  3. King's College London
  4. King's College Hospital National Health Service Foundation Trust

向作者/读者索取更多资源

Flow-mediated dilation of the brachial or radial artery in response to transient hyperaemic flow, the most widely used test of endothelial function, is only manifest after flow decays back to baseline. We examined whether this dissociation of flow and diameter might be explained by a reduction in transmural pressure generated by high flow. Studies were performed in healthy subjects 20 to 55 years of age. Flow-mediated dilation was measured in the radial artery using a standard protocol and after flow interruption at peak hyperemia during brachial artery infusion of saline and the NO synthase inhibitor NG-monomethyl-L-arginine (8 mu mol/min). Flow interruption 20 seconds after cuff release (during high flow but no dilatation) produced an immediate increase in radial artery diameter of 5.36 +/- 2.12%, inhibited by NG-monomethyl-L-arginine to 1.09 +/- 0.67% (n=8; P<0.001). Mean intra-arterial radial blood pressure and, hence, transmural pressure fell after cuff release by a mean of 26 +/- 1.8 mm Hg (n=6; P<0.0001) at the time of peak hyperemic flow. Modulation of transmural pressure within the brachial artery by cuff inflation around the artery demonstrated that this fall is sufficient to reduce arterial diameter by an amount similar to flow-mediated dilation. These results suggest that flow-dependent, NO-dependent dilation is offset by a flow-induced fall in local arterial pressure and, hence, in transmural pressure. Shear related NO release is likely to play a greater role in the short-term regulation of arterial tone than that suggested by flow-mediated dilation. (Hypertension. 2011;57:1145-1150.)

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据