期刊
HYPERTENSION
卷 57, 期 3, 页码 397-U108出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/HYPERTENSIONAHA.110.156828
关键词
blood pressure; epidemiology; morbidity; risk factors; women
资金
- European Union [IC15-CT98-0329-EPOGH, LSHM-CT-2006-037093, HEALTH-F4-2007-201550]
- Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Ministry of the Flemish Community, Brussels, Belgium [G.0575.06, G.0734.09]
- Katholieke Universiteit Leuven [OT/00/25, OT/05/49]
- Y.L. in Leuven
- Danish Heart Foundation [01-2-9-9A-22914]
- Lundbeck Fonden [R32-A2740]
- Ministry of Education, Culture, Sports, Science, and Technology [15790293, 16590433, 17790381, 18390192, 18590587, 19590929, 19790423]
- Ministry of Health, Labor, and Welfare [H17-Kenkou-007, H18 Junkankitou [Seishuu]-Ippan-012, H20-Junkankitou[Seishuu]-Ippan-009, 013]
- Japanese Society for the Promotion of Science [16.54041, 18.54042, 19.7152, 20.7198, 20.7477, 20.54043]
- Japan Atherosclerosis Prevention Fund
- Uehara Memorial Foundation
- Takeda Medical Research Foundation
- National Natural Science Foundation of China, Beijing, China [30871360, 30871081]
- Shanghai Commissions of Science and Technology [07JC14047, 06QA14043, 07ZZ32]
- Grants-in-Aid for Scientific Research [21390201] Funding Source: KAKEN
To analyze sex-specific relative and absolute risks associated with blood pressure (BP), we performed conventional and 24-hour ambulatory BP measurements in 9357 subjects (mean age, 52.8 years; 47% women) recruited from 11 populations. We computed standardized multivariable-adjusted hazard ratios for associations between outcome and systolic BP. During a course of 11.2 years (median), 1245 participants died, 472 of cardiovascular causes. The number of fatal combined with nonfatal events was 1080, 525, and 458 for cardiovascular and cardiac events and for stroke, respectively. In women and men alike, systolic BP predicted outcome, irrespective of the type of BP measurement. Women compared with men were at lower risk (hazard ratios for death and all cardiovascular events=0.66 and 0.62, respectively; P<0.001). However, the relation of all cardiovascular events with 24-hour BP (P=0.020) and the relations of total mortality (P=0.023) and all cardiovascular (P=0.0013), cerebrovascular (P=0.045), and cardiac (P=0.034) events with nighttime BP were steeper in women than in men. Consequently, per a 1-SD decrease, the proportion of potentially preventable events was higher in women than in men for all cardiovascular events (35.9% vs 24.2%) in relation to 24-hour systolic BP (1-SD, 13.4 mm Hg) and for all-cause mortality (23.1% vs 12.3%) and cardiovascular (35.1% vs 19.4%), cerebrovascular (38.3% vs 25.9%), and cardiac (31.0% vs 16.0%) events in relation to systolic nighttime BP (1-SD, 14.1 mm Hg). In conclusion, although absolute risks associated with systolic BP were lower in women than men, our results reveal a vast and largely unused potential for cardiovascular prevention by BP-lowering treatment in women. (Hypertension. 2011;57:397-405.). Online Data Supplement
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