期刊
HYBRIDOMA
卷 27, 期 2, 页码 65-69出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/hyb.2007.0549
关键词
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资金
- NIAID NIH HHS [R01-AI065967] Funding Source: Medline
Affinity-matured human antibodies have demonstrated efficacy as countermeasures for exposure to botulinum neurotoxin (BoNT), which is the cause of the disease botulism category A select bioterror agent. Little is known, however, about the potential role of natural (un-mutated) antibodies in the protective immune response to BoNT. Here we describe the cloning of two human IgM antibodies that bind serotype A BoNT. Both are un-mutated IgM antibodies, consistent with an origin in naive B cells. One of the antibodies is able to fully neutralize a lethal dose of serotype A BoNT in vivo. These results suggest that the natural human antibody repertoire may play a role in protection from exposure to biological toxins.
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