期刊
HUMAN REPRODUCTION
卷 27, 期 9, 页码 2613-2618出版社
OXFORD UNIV PRESS
DOI: 10.1093/humrep/des245
关键词
recurrent pregnancy loss; plasma volume; venous compliance; hemodynamic
More than half of recurrent pregnancy loss (RPL) remains unexplained. We hypothesized that women with a history of unexplained RPL (URPL) have low venous reserve. Casecontrol study in 12 women with a history of URPL, 11 healthy nulliparous controls and 12 primiparous controls with a history of uncomplicated pregnancy. To quantify venous reserve, we measured plasma volume (PV, ml/m(2)) and venous compliance in forearm and calf (VCarm, VCcalf, (ml/dl)/mmHg) during the follicular phase of the menstrual cycle. Mean arterial blood pressure (mmHg) was measured by oscillometry. Arterial demand was evaluated by cardiac index (CI, (l/min)/m(2)). Baseline characteristics were comparable between groups. All groups had similar CI. Women with a history of RPL had 14 and 9 lower mean PV compared with nulliparous and primiparous controls (P 0.01 and P 0.04, respectively). In women with URPL, the mean VCarm was 25 and 32 lower compared with nulliparous and primiparous controls (P 0.04 and P 0.01, respectively), while the mean VCcalf was 29 and 22 lower compared with the two control groups (P 0.01 and P 0.03, respectively). Women with URPL have lower venous reserves when compared with controls at comparable arterial demand. Interventions that increase venous reserve may improve pregnancy outcome.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据