期刊
HUMAN REPRODUCTION
卷 25, 期 5, 页码 1280-1281出版社
OXFORD UNIV PRESS
DOI: 10.1093/humrep/deq033
关键词
ovarian transplantation; ovarian cryopreservation; natural conception
资金
- Danish Cancer Foundation [DP05112/R2-A41-09-S2]
Worldwide eight children have been born as a result of transplanting frozen/thawed ovarian tissue. Two of these children were born in Denmark following transport of the ovarian tissue for a period of 5 h prior to cryopreservation. One of these women, who was originally transplanted with six pieces of ovarian cortex, after having experienced a period of menopause has now conceived again following natural conception. She gave birth to a healthy girl on 23 September 2008 and is therefore the first woman in the world to have had two children, from separate pregnancies, born as a result of transplanting frozen/thawed ovarian tissue. This result encourages further development of cryopreservation of ovarian tissue for fertility preservation as a clinical procedure for girls and young women facing gonadotoxic treatment.
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