期刊
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
卷 29, 期 1, 页码 94-99出版社
WILEY
DOI: 10.1002/hup.2374
关键词
anxiety; public speaking test; rimonabant; SR141716; CB1 receptor
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2009/11805-4]
- CNPq (Brazil)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [09/11805-4] Funding Source: FAPESP
ObjectiveWe investigated the hypothesis that rimonabant, a cannabinoid antagonist/inverse agonist, would increase anxiety in healthy subjects during a simulation of the public speaking test. MethodsParticipants were randomly allocated to receive oral placebo or 90mg rimonabant in a double-blind design. Subjective effects were measured by Visual Analogue Mood Scale. Physiological parameters, namely arterial blood pressure and heart rate, also were monitored. ResultsTwelve participants received oral placebo and 12 received 90mg rimonabant. Rimonabant increased self-reported anxiety levels during the anticipatory speech and performance phase compared with placebo. Interestingly, rimonabant did not modulate anxiety prestress and was not associated with sedation, cognitive impairment, discomfort, or blood pressure changes. ConclusionsCannabinoid-1 antagonism magnifies the responses to an anxiogenic stimulus without interfering with the prestress phase. These data suggest that the endocannabinoid system may work on-demand to counteract the consequences of anxiogenic stimuli in healthy humans. Copyright (c) 2013 John Wiley & Sons, Ltd.
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