期刊
HUMAN PATHOLOGY
卷 44, 期 9, 页码 1737-1746出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.humpath.2013.02.010
关键词
Hodgkin lymphoma; Nodular lymphocyte predominant Hodgkin lymphoma; Intranodular clusters of activated cells; Activated T cells; T follicular helper cells (T-FH); PD1; CXCL13; Rosettes
类别
资金
- Deutsche Forschungsgemeinschafl (DFG) [HA 6145/1-1]
In nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), little is known about the presence of intranodular clusters of cytologically activated lymphoid cells producing a moth-eaten pattern histologically. This pilot study of 32 NLPHL cases from Finland ascertained (1) the frequency of the intranodular clusters of activated lymphoid cells, (2) the immunophenotype of the activated cells, (3) the size and immunophenotype of the rosetting cells, and (4) the clinical significance of the activated cells. Histologically, intranodular clusters of activated cells produced a moth-eaten pattern in 100% (32 cases; subtle in 62.5%, overt in 37.5%). In immunostains, activated cells in subtle clusters (20 cases) were very difficult to identify. Twelve cases had overt clusters of activated cells, which were positive with CD3, CD4, PD1, CXCL13 (T follicular helper [T-FH] phenotype), but rarely with Ki-67 and BCL2. Most activated rosetting cells had the same immunophenotype as the nonrosetting cells, except for CXCL13. Clinical presentation for all 32 Finnish patients was distinctive: 97% men, 97% with peripheral lymphadenopathy and 35.5% with stage III/IV disease. Only 22% relapsed; 97% were in remission. There was no significant clinical difference between cases with overt and subtle clusters. Intranodular activated T-FH cells in NLPHL appeared to be nonproliferating and not long-living, and they were not associated with any adverse clinical outcome. Although most activated cells were T-FH cells, it seemed that they were unable to increase the number of malignant cells. The pathogenetic role of the intranodular activated T-FH and the small T cells in NLPHL needs further investigation. (C) 2013 Elsevier Inc. All rights reserved.
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