期刊
HUMAN PATHOLOGY
卷 44, 期 11, 页码 2614-2618出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.humpath.2013.04.027
关键词
FGF23; Giant cells; Phosphaturic mesenchymal tumors of the mixed connective tissue type; Pulmonary metastasis
类别
资金
- Japanese Ministry of Education, Culture, Sports, Science and Technology for Scientific Research [24791553]
- Koike Hospital
- Sasebo Central Hospital
- Yamada Clinic
- Grants-in-Aid for Scientific Research [24791553] Funding Source: KAKEN
Phosphaturic mesenchymal tumors of the mixed connective tissue type (PMT-MCTs) are rare neoplasms, most of which are benign and cause tumor-induced osteomalacia because of overproduction of a phosphaturic hormone, fibroblast growth factor 23 (FGF23). This entity may have been unrecognized or misdiagnosed as other mesenchymal tumors, such as giant cell tumor, hemangiopericytoma, and osteosarcoma. Ten percent of these tumors, without phosphaturia, were diagnosed only by their histologic features. We report here the first case of malignant PMT-MCT, nonphosphaturic variant, resulting in fatal multiple lung metastases. Chondromyxoid matrix with grungy calcification, multinucleated giant cell proliferation, and expression of FGF23 mRNA (reverse transcription-polymerase chain reaction) and fibroblast growth factor 23 protein (immunohistochemistry) were seen in the primary and recurrent tumors of the right foot. The lung metastases showed flocculent calcification and FGF23 protein expression as well as giant cell proliferation. This unique case highlights the need for careful histologic assessment of PMT-MCTs, especially the nonphosphaturic variant, and the need for recognition of its rare malignant behavior. (C) 2013 Elsevier Inc. All rights reserved.
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