期刊
HUMAN MUTATION
卷 32, 期 9, 页码 1004-1007出版社
WILEY
DOI: 10.1002/humu.21539
关键词
BRCA1; BRCA2; microRNA; SNP; breast cancer; cancer risk
资金
- Ligue Nationale contre le Cancer
- Association for International Cancer Research [AICR-07-0454]
- Association Le cancer du sein, parlons-en!.
- programme Labellisation des equipes
- Cancer Research-UK [C12292/A11168]
- Cancer Research UK [11668, 11174] Funding Source: researchfish
The rs2910164:G>C SNP is located in the gene for miR-146a, a microRNA that binds the 3' UTR of the BRCA1 transcript. Preliminary data based on the analysis of a small number of cases suggested that this single nucleotide polymorphism (SNP) might be associated with the age of onset of familial breast and ovarian cancer. This effect was not confirmed on a large series of familial breast cancer cases negative for a BRCA1 or BRCA2 mutation. We show here a lack of association of the rs2910164:G>C SNP with breast cancer risk in a series of 1,166 BRCA1 and 560 BRCA2 mutation carriers. In conclusion, the polymorphism in the miR-146a gene is unlikely to be of substantial significance regarding breast cancer risk. Hum Mutat 32:1004-1007, 2011. (C) 2011 Wiley-Liss, Inc.
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