期刊
HUMAN MUTATION
卷 32, 期 6, 页码 E2148-E2175出版社
WILEY-BLACKWELL
DOI: 10.1002/humu.21477
关键词
Somatic mutation; Melanoma; ADAM7; ADAM29
资金
- National Human Genome Research Institute, National Institutes of Health
- Ministerio de Ciencia e Innovacion-Spain
- Fundacion M. Botin
- European Union
We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression. (C) 2011 Wiley-Liss, Inc.
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