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注意：仅列出部分参考文献，下载原文获取全部文献信息。A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent
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Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver
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Effects of dietary broccoli on human in vivo caffeine metabolism: A pilot study on a group of Jordanian volunteers
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Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics
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Female sex and oral contraceptive use accelerate nicotine metabolism
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Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy
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Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5
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Limitation of cigarette consumption by CYP2A6*4, *7 and *9 polymorphisms
N Minematsu et al.
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Ethnic and racial differences in the smoking-related risk of lung cancer
CA Haiman et al.
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Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations
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Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen
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A novel CYP2A6*20 allele found in African-American population produces a truncated protein lacking enzymatic activity
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Three haplotypes associated with CYP2A6 phenotypes in Caucasians
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Ethnic variation in CYP2A6*7, CYP2A6*8 and CYP2A6*10 as assessed with a novel haplotyping method
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PHARMACOGENETICS AND GENOMICS (2005)
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Effects of chronic exposure to low-level cadmium on renal tubular function and CYP2A6-mediated coumarin metabolism in healthy human subjects
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Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians
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Metabolic profile of nicotine in subjects whose CYP2A6 gene is deleted
H Yamanaka et al.
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Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers
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A novel polymorphism of human CYP2A6 gene CTP2A6*17 has an amino acid substitution (V365M) that decreases enzymatic activity in vitro and in vivo
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Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity
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Polymorphic NF-Y dependent regulation of human nicotine C-oxidase (CYP2A6)
O von Richter et al.
PHARMACOGENETICS (2004)
Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population
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PHARMACOGENOMICS (2004)
Whole deletion of CYP2A6 gene (CYP2A6*4C) and smoking behavior
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NEUROPSYCHOBIOLOGY (2004)
A nicotine C-oxidase gene (CYP2A6) polymorphism important for promoter activity
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HUMAN MUTATION (2004)
Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration
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MOLECULAR PHARMACOLOGY (2003)
Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes
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Catalog of 680 variations among eight cytochrome P450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population
S Saito et al.
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Genetic polymorphisms in human CYP2A6 gene causing impaired nicotine metabolism
R Yoshida et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2002)
Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19
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PHARMACOGENETICS (2001)
Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene:: Impairment of its promoter activity
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
CYP2A6*6, a novel polymorphism in cytochrome P450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit
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