期刊
LEGAL MEDICINE
卷 17, 期 1, 页码 14-16出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.legalmed.2014.08.004
关键词
Gene deletion; Geographic distribution; Ancestry informative marker; Anaphylaxis
资金
- Ministry of Education, Science, Culture and Sports of Japan
- Ishibashi Foundation
- Grants-in-Aid for Scientific Research [26550083, 26220103] Funding Source: KAKEN
The haptoglobin (HP) gene deletion allele (HPdel) is responsible for anhaptoglobinemia and a genetic risk factor for anaphylaxis reaction after transfusion due to production of the anti-HP antibody. The distribution of this allele has been explored by several groups including ours. Here, we studied the frequency of HPdel in addition to the distribution of common HP genotypes in 293 Vietnamese. The HPdel was encountered with the frequency of 0.020. The present result suggested that this deletion allele is restricted to East and Southeast Asians. Thus, this allele seems to be a potential ancestry informative marker for these populations. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据