期刊
HUMAN MOLECULAR GENETICS
卷 22, 期 12, 页码 2539-2550出版社
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddt089
关键词
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资金
- US NIH [R01CA124558, R01CA148667, R01CA64277, R37CA070867, U19 CA148065, R01CA118229, R01CA0 92585, R01CA122756, R01 CA137013, R01CA63464, R01CA54281, CA132839]
- Ingram Professorship funds
- Cancer Research UK [C1287/A10118, C1287/A12014, C1287/A10710]
- European Community [223175 (HEALTH-F2-2009-223175)]
- European Union COST program [BM0606]
- European Union [HEALTH-F2-2009-223175]
- Canadian Institutes of Health Research
- Ministry of Economic Development, Innovation and Export Trade of Quebec [PSR-SIIRI-701]
- Vanderbilt-Ingram Cancer Center [P30 CA68485]
- US Department of Defense Breast Cancer Research Program [BC011118, BC050791]
- National Research Foundation
- Ministry of Education, Science and Technology
- National Biobank of Korea and National R&D Program of the Republic of Korea [2011-0001564, 1020350, 0620410-1, 2012-0000347, KOBB-2011-03]
- National Natural Science Foundation of China [09KJA330001, 30771844, 81072383]
- Taiwan Biobank [DOH97-01]
- Hong Kong Research Grant Council [7520/05M, 76730M]
- Japanese Ministry of Health, Labor and Welfare and Ministry of Education [17015049, 221S0001, 17015052, H20-002]
- Marit and Hans Rausings Initiative Against Breast Cancer
- Cancer Risk Prediction Center, a Linneus Centre [70867902]
- Swedish Research Council
- Grants-in-Aid for Scientific Research [24590776, 17015049, 17015052] Funding Source: KAKEN
- Korea Health Promotion Institute [1020350, 0620410] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Cancer Research UK [16565, 11022, 10118] Funding Source: researchfish
In a consortium including 23 637 breast cancer patients and 25 579 controls of East Asian ancestry, we investigated 70 single-nucleotide polymorphisms (SNPs) in 67 independent breast cancer susceptibility loci recently identified by genome-wide association studies (GWASs) conducted primarily in European-ancestry populations. SNPs in 31 loci showed an association with breast cancer risk at P 0.05 in a direction consistent with that reported previously. Twenty-one of them remained statistically significant after adjusting for multiple comparisons with the Bonferroni-corrected significance level of 0.0015. Eight of the 70 SNPs showed a significantly different association with breast cancer risk by estrogen receptor (ER) status at P 0.05. With the exception of rs2046210 at 6q25.1, the seven other SNPs showed a stronger association with ER-positive than ER-negative cancer. This study replicated all five genetic risk variants initially identified in Asians and provided evidence for associations of breast cancer risk in the East Asian population with nearly half of the genetic risk variants initially reported in GWASs conducted in European descendants. Taken together, these common genetic risk variants explain 10 of excess familial risk of breast cancer in Asian populations.
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