期刊
HUMAN MOLECULAR GENETICS
卷 22, 期 13, 页码 2748-2753出版社
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddt109
关键词
-
资金
- Intramural Research Program of the National Cancer Institute
- Westat, Inc.
- California Cancer Research Program [99-00505V-10260, 03-00174VRS-30021]
- National Cancer Institute [1R01 CA102042-01A1]
- Whittier Foundation
- Abramson Cancer Center at the University of Pennsylvania
- National Institutes of Health [R01CA114478, R01CA085914]
- MD Anderson Senior Research Trust Fellowship
- Movember
- Cancer Research UK
- [HHSN261200655004C]
- Cancer Research UK [10589] Funding Source: researchfish
Genome-wide association studies (GWASs) have identified multiple common genetic variants associated with an increased risk of testicular germ cell tumors (TGCTs). A previous GWAS reported a possible TGCT susceptibility locus on chromosome 1q23 in the UCK2 gene, but failed to reach genome-wide significance following replication. We interrogated this region by conducting a meta-analysis of two independent GWASs including a total of 940 TGCT cases and 1559 controls for 122 single-nucleotide polymorphisms (SNPs) on chromosome 1q23 and followed up the most significant SNPs in an additional 2202 TGCT cases and 2386 controls from four casecontrol studies. We observed genome-wide significant associations for several UCK2 markers, the most significant of which was for rs3790665 (P-Combined 6.0 10(9)). Additional support is provided from an independent familial study of TGCT where a significant over-transmission for rs3790665 with TGCT risk was observed (P-FBAT 2.3 10(3)). Here, we provide substantial evidence for the association between UCK2 genetic variation and TGCT risk.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据