4.5 Article

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16

Xiangming Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Clinical Neurology

The Biology and Pathology of the Familial Parkinson's Disease Protein LRRK2

William Dauer et al.

MOVEMENT DISORDERS (2010)

Article Biochemistry & Molecular Biology

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

Byoung Dae Lee et al.

NATURE MEDICINE (2010)

Article Neurosciences

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

Mark R. Cookson

NATURE REVIEWS NEUROSCIENCE (2010)

Review Neurosciences

Neurodegenerative disorders: Insights from the nematode Caenorhabditis elegans

Maria Dimitriadi et al.

NEUROBIOLOGY OF DISEASE (2010)

Review Neurosciences

Genetic Animal Models of Parkinson's Disease

Ted M. Dawson et al.

NEURON (2010)

Article Biochemistry & Molecular Biology

Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2

Jason P. Covy et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Biochemistry & Molecular Biology

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

R. Jeremy Nichols et al.

BIOCHEMICAL JOURNAL (2009)

Article Biochemistry & Molecular Biology

Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

Katerina Venderova et al.

HUMAN MOLECULAR GENETICS (2009)

Article Biochemistry & Molecular Biology

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

Christian Johannes Gloeckner et al.

JOURNAL OF NEUROCHEMISTRY (2009)

Article Neurosciences

LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans

Shamol Saha et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Neurosciences

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

Luke S. Tain et al.

NATURE NEUROSCIENCE (2009)

Review Genetics & Heredity

Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants

Derek Lessing et al.

NATURE REVIEWS GENETICS (2009)

Article Biochemistry & Molecular Biology

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

Yuzuru Imai et al.

EMBO JOURNAL (2008)

Article Biochemistry & Molecular Biology

Ancient origin of the Parkinson disease gene LRRK2

Ignacio Marin

JOURNAL OF MOLECULAR EVOLUTION (2008)

Article Medicine, General & Internal

Sorafenib in advanced hepatocellular carcinoma

Josep M. Llovet et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Multidisciplinary Sciences

A Drosophila model for LRRK2-linked parkinsonism

Zhaohui Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

Shusei Hamamichi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

Aaron D. Gitler et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

Andrew B. West et al.

HUMAN MOLECULAR GENETICS (2007)

Article Neurosciences

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Wanli W. Smith et al.

NATURE NEUROSCIENCE (2006)

Article Multidisciplinary Sciences

α-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

Antony A. Cooper et al.

SCIENCE (2006)

Article Multidisciplinary Sciences

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

WW Smith et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

AB West et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

α-synuclein locus triplication causes Parkinson's disease

AB Singleton et al.

SCIENCE (2003)

Article Multidisciplinary Sciences

Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

R Nass et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Chemistry, Medicinal

The discovery of potent cRaf1 kinase inhibitors

K Lackey et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2000)