期刊
HUMAN MOLECULAR GENETICS
卷 20, 期 20, 页码 4076-4081出版社
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddr325
关键词
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资金
- European Union [LSHM-CT-2006-037761, PIAP-GA-2008-218251, HEALTH-F2-2009-223423]
- National Genome Research Network of the German Federal Ministry of Education and Research (BMBF) [01GS08144, 01GS08147]
- National Institute of Mental Health [R01 MH078075, N01 MH900001, MH074027]
- Centre of Excellence for Complex Disease Genetics of the Academy of Finland [213506, 129680]
- Biocentrum Helsinki Foundation
- Faculty of Medicine, University of Helsinki
- Stanley Medical Research Institute
- Danish Council for Strategic Research [2101-07-0059]
- H. Lundbeck A/S
- Research Council of Norway [163070/V50]
- South-East Norway Health Authority [2004-123]
- Medical Research Council
- Ministerio de Sanidad y Consumo, Spain [PI081522]
- Xunta de Galicia [08CSA005208PR]
- Swedish Research Council
- Wellcome Trust [083948/Z/07/Z]
- Max Planck Society
- Eli Lilly and Company
- Wellcome Trust [083948/Z/07/Z] Funding Source: Wellcome Trust
- MRC [G0800509] Funding Source: UKRI
- Medical Research Council [G0800509, G0801418B, G9817803B] Funding Source: researchfish
Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 x 10(-9)] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 x 10(-9)).
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