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注意：仅列出部分参考文献，下载原文获取全部文献信息。TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action
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The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men
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Unique splicing pattern of the TCF7L2 gene in human pancreatic islets
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Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function
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MOLECULAR AND CELLULAR BIOLOGY (2009)
Alternative Splicing of TCF7L2 Gene in Omental and Subcutaneous Adipose Tissue and Risk of Type 2 Diabetes
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TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic β-cells
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BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
The transcription factor 7-like 2 gene and increased risk of type 2 diabetes: an update
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CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2008)
New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function
John R. B. Perry et al.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2008)
Mice with beta cell overexpression of glycogen synthase kinase-3β have reduced beta cell mass and proliferation
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被撤回的出版物: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets(Retracted article. See vol. 66, pg. 1729, 2017)
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Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
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JOURNAL OF CLINICAL INVESTIGATION (2007)
The new type 2 diabetes gene TCF7L2
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CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2007)
Inhibition of GSK3 promotes replication and survival of pancreatic beta cells
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Wnt signaling regulates pancreatic β cell proliferation
Ingrid C. Rulifson et al.
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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
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A genome-wide association study identifies novel risk loci for type 2 diabetes
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TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription
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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
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Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes
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H Ma et al.
ONCOGENE (2005)
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Translational control is required for the unfolded protein response and in vivo glucose homeostasis
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Diabetes mellitus and exocrine pancreatic dysfunction in Perk-/- mice reveals a role for translational control in secretory cell survival
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MOLECULAR CELL (2001)
Inhibition of GSK-3 selectively reduces glucose-B-phosphatase and phosphoenolpyruvate carboxykinase gene expression
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Identification and purification of functional human β-cells by a new specific zinc-fluorescent probe
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Human islet transplantation -: Lessons from 13 autologous and 13 allogeneic transplantations
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