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Sequence determinants for amyloid fibrillogenesis of human α-synuclein
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Transgenic mouse models of amyotrophic lateral sclerosis
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2006)
β-synuclein modulates α-synuclein neurotoxicity by reducing α-synuclein protein expression
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α-synuclein cooperates with CSPα in preventing neurodegeneration
S Chandra et al.
CELL (2005)
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NEUROBIOLOGY OF DISEASE (2005)
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Mouse model of multiple system atrophy α-synuclein expression in oligodendrocytes causes glial and neuronal degeneration
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Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina
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A Maatkamp et al.
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Hsp70 reduces α-synuclein aggregation and toxicity
J Klucken et al.
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Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of γ-synuclein, α-synuclein and double α/γ-synuclein null mutant mice
DC Robertson et al.
JOURNAL OF NEUROCHEMISTRY (2004)
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Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy
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NATURE GENETICS (2004)
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LI Bruijn et al.
ANNUAL REVIEW OF NEUROSCIENCE (2004)
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R Perez-Olle et al.
HUMAN MOLECULAR GENETICS (2004)
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JOURNAL OF NEUROBIOLOGY (2004)
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EUROPEAN JOURNAL OF NEUROSCIENCE (2003)
Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation
S Gispert et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2003)
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CA da Costa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Ubiquitination of α-synuclein is not required for formation of pathological inclusions in α-synucleinopathies
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KK Dev et al.
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JY Park et al.
BIOCHEMISTRY (2003)
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T Gomez-Isla et al.
NEUROBIOLOGY OF AGING (2003)
Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene
N Ninkina et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
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R Perez-Olle et al.
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Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53→Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice
MK Lee et al.
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Differential neuropathological alterations in transgenic mice expressing α-synuclein from the platelet-derived growth factor and Thy-1 promoters
E Rockenstein et al.
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E Masliah et al.
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Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease
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AR Saha et al.
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JE Galvin et al.
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A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene
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SCIENCE (2000)