期刊
HUMAN IMMUNOLOGY
卷 75, 期 8, 页码 940-944出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2014.06.023
关键词
Narcolepsy; Cytokine; Sleep; IL-8; G-CSF
类别
资金
- JSPS KAKENHI [23700458]
- Grants-in-Aid for Scientific Research [26870117, 23700458] Funding Source: KAKEN
Narcolepsy is a chronic hypersomnia involving excessive daytime sleepiness and cataplexy. Some susceptibility genes and environmental factors suggest that post-infectious immunological alterations underlie its pathophysiology. To investigate the immunological alterations in narcolepsy patients, we examined cytokines. Nine healthy controls and twenty-one narcolepsy patients with cataplexy were studied. All subjects were positive for the HLA-DRB1*1501-DQB1*0602 allele. Age-, sex-, and body mass index -matched healthy controls were selected. Plasma samples were separated using EDTA-2 K-coated blood collection tubes. Bioplex Pro Human Cytokine 17-Plex Assays were used to measure plasma cytokines. Elevations of interleukin (IL)-6, IL-8, granulocyte- colony stimulating factor (G-CSF), and tumor necrosis factor-alpha were found in the narcolepsy group compared with healthy controls (p < 0.05). G-CSF values were significantly correlated with the disease duration in narcolepsy patients (r = 0.426, p < 0.05). IL-8 and G-CSF play major roles in neutrophil activation in respiratory diseases. Since environmental factors including infection are reportedly associated with narcolepsy onset, elevated IL-8 and G-CSF may be involved in the pathophysiology of narcolepsy. (C) 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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