期刊
HUMAN IMMUNOLOGY
卷 74, 期 7, 页码 849-851出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2013.03.004
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资金
- Prinses Beatrix Spierfonds
- Koningin Wilhelmina Foundation
- Association Francaise contre les Myopathies
Lambert Eaton myasthenic syndrome (LEMS) is characterized by fluctuating muscle weakness and autonomic dysfunction. In 90% of the LEMS patients the disease is associated with auto-antibodies against the voltage-gated calcium channels (VGCC). Several auto-immune responses against other antigenic targets have been described to (co)-occur in LEMS patients. To identify new LEMS associated small cell lung cancer (SCLC) markers immunoprecipitation with a SCLC cell line was performed. We discovered strong immunoreactivity against the 120 kDa large ERC1 protein in one tumor-negative VGCC-positive LEMS patient. A recombinant ELISA assay and a cellular assay expressing GFP-tagged full length ERC1 were used to confirm the presence of auto-antibodies against ERC1 in this patient. Additional testing of 58 LEMS patients including 9 VGCC auto-antibody negative LEMS patients, 48 myasthenia gravis patients, 84 control patients with other diseases and 12 healthy controls revealed no other cases. ERC1 is therefore a new, but rare, antigen in LEMS. (c) 2013 American Society for Histocompatibility and Immunogenetics. Published byElsevier Inc. All rights reserved.
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