期刊
HUMAN IMMUNOLOGY
卷 74, 期 2, 页码 170-175出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2012.11.007
关键词
-
类别
资金
- Japan Society for the Promotion of Science [22390199, 22591090]
- Ministry of Health, Labour, and Welfare of Japan
- National Hospital Organization
- Daiwa Securities Health Foundation
- Japan Research Foundation for Clinical Pharmacology
- Nakatomi Foundation
- Takeda Science Foundation
- Abbott Japan Co., Ltd.
- Astellas Pharma Inc.
- Chugai Pharmaceutical Co., Ltd.
- Eisai Co., Ltd.
- Mitsubishi Tanabe Pharma Corporation
- Merck Sharp and Dohme Inc.
- Pfizer Japan Inc.
- Takeda Pharmaceutical Company Limited
- Teijin Pharma Limited
- Grants-in-Aid for Scientific Research [22390199, 22591090] Funding Source: KAKEN
Information to distinguish genetic and environmental factors in the pathogenesis of multifactorial diseases can be obtained by investigation of disease development in monozygotic twins. Recent reports have shown that there are genomic and epigenomic differences between monozygotic twins. Genomic/epigenomic and gene expression analyses were performed in monozygotic twins discordant for systemic lupus erythematosus (SLE) to find the genes playing important roles in SLE pathogenesis. Single nucleotide polymorphism (SNP) and copy number variation (CNV) typing, CpG methylation and gene expression were analyzed. The discordances in SNPs and CNVs were not confirmed. Both CpG methylation and gene expression levels were different for 10 genes. There were no genomic differences between monozygotic twins discordant for SLE, but epigenomic and gene expression differences were detected. These findings provide information for better understanding of SLE pathogenesis. (c) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据