期刊
HUMAN IMMUNOLOGY
卷 70, 期 12, 页码 1016-1019出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2009.07.026
关键词
Virus; HLA-G; Influenza; Flu; Immune escape
类别
资金
- Projet Transversal de Recherche INRA-Institut Pasteur
- Agence Nationale de la Recherche
Influenza virus type A (IAV) infections constitute an important economic burden and raise health-care problems. Host defense mechanisms usually clear IAV infections after a few days by exploiting a variety of cellular immune responses. However, increasing the production of immunosubversive molecules is a mechanism by which viruses escape host surveillance. In this regard, the nonclassical HLA class I molecule HLA-G displays strong tolerogenic properties. We show here that several strains of IAV differently upregulate HLA-G expression, at both the mRNA and protein levels, in alveolar epithelial cells. Thus the virulence of IAV may be caused by the capability of different strains to upregulate HLA-G allowing their escape from host immune responses. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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