期刊
HUMAN IMMUNOLOGY
卷 70, 期 5, 页码 325-330出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2009.02.008
关键词
Macrophages; Polarization; Cytokines; Inflammation; Cancer; Cancer-related inflammation; Monocytes; Myeloid-derived suppressor cells
类别
资金
- Associazione Italiana per la Ricerca SUI Cancro (AIRC)
- CARIPLO Nobel
Macrophages undergo a wide spectrum of polarized activation states, and have the potential both to elicit tumor and tissue destructive reactions and to promote tumor progression (macrophage balance). In general, tumor-associated macrophages (TAM) from established tumors and the related myeloid-derived suppressor cells are diverse and have properties of M2-activated cells. As such, they help cancer progression and metastasis. Therefore, TAM are a key component of pathways connecting inflammation and cancer. (C) 2009 American Society for Histocompatibility and Immunogenetics. published by Elsevier Inc. All rights reserved.
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