期刊
HUMAN IMMUNOLOGY
卷 70, 期 5, 页码 321-324出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2009.02.006
关键词
Dendritic cells; Rheumatoid arthritis; Tolerance induction; Immunotherapy
类别
资金
- EULAR
- Dutch Arthritis Association [07010 14]
Dendritic cells (DC) comprise a complex network of heterogeneous antigen-presenting cells (APC) that are critical not only to the initiation and regulation of adaptive immunity (Th1/Th2/Th17 responses), but also to the maintenance of both central and peripheral tolerance (regulatory T cells, peripheral T-cell deletion). Previous work has clearly indicated a role for DC subsets in the pathogenesis of rheumatoid arthritis (RA). Therefore, utilizing these cells as therapeutic agents could be beneficial in the treatment of RA. However, it remains unclear which DC should be used for tolerance-inducing immunotherapy: myeloid, plasmacytoid, or both? This review summarizes the data obtained thus far concerning the functional characterization of several DC subsets in human RA and accordingly explores their potential use for immunotherapy. (C) 2009 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.
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