Therapeutic potential of FOXP3+ regulatory T cells and their interactions with dendritic cells

FOXP3(+) regulatory T cells, a unique subset of T cells, are critical for orchestrating an immune response and preventing Self-reactivity. With) the increasing prevalence and unsatisfactory treatment of autoimmunity, allergic diseases, cancer and chronic infections, much attention has been focused on understanding their mechanisms of action in order to manipulate their function. One goal is to develop drugs or biologics that can enhance or abrogate their functions. Another approach is to utilize Tregs in adoptive cell-based therapy to treat autoimmune diseases or transplant-related complications. This review will focus on their therapeutic potential and mechanisms of action, particularly their interaction with dendritic cells. Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.