期刊
HUMAN IMMUNOLOGY
卷 69, 期 11, 页码 681-686出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2008.08.286
关键词
ILT3; CD8-T suppressor cells; Transplantation; Cancer; Allergy
类别
Similar to helper and cytotoxic T cells, CD8(+) T suppressor cells (Ts) acquire antigen specificity via direct interaction with antigen-presenting cells (APC). They induce the upregulation of the inhibitory receptor immunoglobulin-like transcript (ILT)3 on professional and nonprofessional APC, rendering these cells tolerogenic and able to induce the differentiation of further waves of regulatory and suppressor T cells. This review sums up evidence that ILT3 is the centerpiece of CD8(+) Ts-driven suppression and acts as a master switch in the regulation of CD8(+) and CD4(+) T-cell responses to antigens in transplantation, autoimmunity, allergy, and cancer. (c) 2008 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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