期刊
HUMAN HEREDITY
卷 68, 期 3, 页码 182-191出版社
KARGER
DOI: 10.1159/000224638
关键词
Population stratification; Coancestry coefficient; Single nucleotide polymorphism; Allele sharing distance
资金
- NIH [R01HL08770002S1, U01AG02374605, GM45344, NS39764]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM045344] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P50NS039764] Funding Source: NIH RePORTER
There is a long history of using allele sharing distance (ASD) and closely related metrics for population stratification analysis. However, the theory for this practical usage has not been reported. In this paper, we describe the theoretical background for using ASD on single nucleotide polymorphism ( SNP) genetic data for human population stratification analysis. In showing the proof, we lay the ground work for a general distance-based method for classifying subpopulations using SNPs and ASD. We also show its relation to other closely related distance metrics using HapMap Phase I SNP data. Copyright (C) 2009 S. Karger AG, Basel
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