期刊
HUMAN GENETICS
卷 126, 期 6, 页码 843-849出版社
SPRINGER
DOI: 10.1007/s00439-009-0737-3
关键词
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资金
- China National Basic Research Program [2007CB512000, 2009CB521901]
- China National 863 Scientific Program [2006AA02Z476]
- National Natural Science Foundation of China [30670857, 30800457]
Atrial fibrillation (AF) is the most common arrhythmia in the clinical setting and an independent risk factor for stroke. Approximately 10 million Chinese people are affected by AF, but the genetic basis is largely unknown. A recent genome-wide association study in Iceland identified association between SNP rs2200733 on 4q25 and AF; however, many independent replication studies are essential to unequivocally validate this association. To assess the association between rs2200733 and AF as well as that between rs2200733 and ischemic stroke in a mainland Chinese Han population, we carried out case-control association studies with 383 AF patients versus 851 non-AF controls and 811 ischemic stroke patients versus 688 non-stroke controls. Highly significant association was detected between rs2200733 and AF in a Chinese Han population (allelic P = 3.7 x 10(-11) with OR = 1.81; genotypic P = 4.1 x 10(-12) with a dominant model). When the AF cases were divided into lone AF (32.6%) and other types of AF (67.4%), significantly stronger association was found with lone AF (OR = 2.40, P = 1.3 x 10(-9) compared to OR = 1.59, P = 6.2 x 10(-7) for other types of AF; P = 0.02 for two ORs). No significant association was found between rs2200733 and ischemic stroke. Our results suggest that SNP rs2200733 confers a highly significant risk of AF, but not ischemic stroke, in a more representative Chinese Han population in the mainland China.
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