相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O6-methylguanine-DNA methyltransferaseP140K
P. Maier et al.
GENE THERAPY (2010)
Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipients
Brian C. Beard et al.
BLOOD (2009)
Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy
Barbara Cassani et al.
BLOOD (2009)
Phase II Trial of Gliadel plus O6-Benzylguanine in Adults with Recurrent Glioblastoma Multiforme
Jennifer A. Quinn et al.
CLINICAL CANCER RESEARCH (2009)
QuickMap: a public tool for large-scale gene therapy vector insertion site mapping and analysis
J-U Appelt et al.
GENE THERAPY (2009)
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
Eugenio Montini et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Transcriptional Enhancers Induce Insertional Gene Deregulation Independently From the Vector Type and Design
Giulietta Maruggi et al.
MOLECULAR THERAPY (2009)
Genomic and Functional Assays Demonstrate Reduced Gammaretroviral Vector Genotoxicity Associated With Use of the cHS4 Chromatin Insulator
Chang Long Li et al.
MOLECULAR THERAPY (2009)
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Da Wei Huang et al.
NATURE PROTOCOLS (2009)
Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy
Nathalie Cartier et al.
SCIENCE (2009)
Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoletic stem cells
Michael D. Milsom et al.
CANCER RESEARCH (2008)
Clinical Application of Lentiviral Vectors - Concepts and Practice
Axel Schambach et al.
CURRENT GENE THERAPY (2008)
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
Steven J. Howe et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
Salima Hacein-Bey-Abina et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16
U. Modlich et al.
LEUKEMIA (2008)
Physiological promoters reduce the genotoxic risk of integrating gene vectors
Daniela Zychlinski et al.
MOLECULAR THERAPY (2008)
Globin lentiviral vector insertions can perturb the expression of endogenous genes in β-thalassemic hematopoietic cells
Phillip W. Hargrove et al.
MOLECULAR THERAPY (2008)
MDR1 gene transfer using a lentiviral SIN vector confers radioprotection to human CD34+ hematopoietic progenitor cells
Patrick Maier et al.
RADIATION RESEARCH (2008)
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
Annette Deichmann et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Real-Time Definition of Non-Randomness in the Distribution of Genomic Events
Ulrich Abel et al.
PLOS ONE (2007)
The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription
Wafa Al-Kandari et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Correlation between O6-methylguanine-DNA methyltransferase and survival in inoperable newly diagnosed glioblastoma patients treated with neoadjuvant temozolomide
Olivier L. Chinot et al.
JOURNAL OF CLINICAL ONCOLOGY (2007)
The Use of Coded PCR Primers Enables High-Throughput Sequencing of Multiple Homolog Amplification Products by 454 Parallel Sequencing
Jonas Binladen et al.
PLOS ONE (2007)
Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity
Ute Modlich et al.
BLOOD (2006)
Lentiviral vector integration sites in human NOD/SCID repopulating cells
Stephanie Laufs et al.
JOURNAL OF GENE MEDICINE (2006)
Fragile sites are preferential targets for integrations of MLV vectors in gene therapy
A. C. Bester et al.
GENE THERAPY (2006)
Characterization and clinical application of human CD34+ stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor
Myrtle Y. Gordon et al.
STEM CELLS (2006)
Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque
Ruth Seggewiss et al.
BLOOD (2006)
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
MG Ott et al.
NATURE MEDICINE (2006)
Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase:: Phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors
M Ranson et al.
CLINICAL CANCER RESEARCH (2006)
Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells
A Recchia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma
JA Quinn et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Genome sequencing in microfabricated high-density picolitre reactors
M Margulies et al.
NATURE (2005)
Long-term persistence of a nonintegrated lentiviral vector in mouse hematopoietic stem cells
AV Terskikh et al.
EXPERIMENTAL HEMATOLOGY (2005)
Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking
O Kustikova et al.
SCIENCE (2005)
MGMT gene silencing and benefit from temozolomide in glioblastoma
ME Hegi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
R Stupp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy
T Neff et al.
BLOOD (2005)
Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments
R Breitling et al.
FEBS LETTERS (2004)
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences
RS Mitchell et al.
PLOS BIOLOGY (2004)
Lentivirus-mediated expression of mutant MGMTP140K protects human CD34+ cells against the combined toxicity of O6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide
D Chinnasamy et al.
HUMAN GENE THERAPY (2004)
RTCGD: retroviral tagged cancer gene database
K Akagi et al.
NUCLEIC ACIDS RESEARCH (2004)
The (CGG)n repeat element within the 5′ untranslated region of the FMR1 message provides both positive and negative cis effects on in vivo translation of a downstream reporter
LS Chen et al.
HUMAN MOLECULAR GENETICS (2003)
Transcription start regions in the human genome are favored targets for MLV integration
XL Wu et al.
SCIENCE (2003)
Genetic alterations in cancer as a result of breakage at fragile sites
NC Popescu
CANCER LETTERS (2003)
Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells
S Laufs et al.
BLOOD (2003)
Side effects of retroviral gene transfer into hematopoietic stem cells
C Baum et al.
BLOOD (2003)
Development of virus vectors for gene therapy of β chain hemoglobinopathies:: flanking with a chromatin insulator reduces γ-globin gene silencing in vivo
DW Emery et al.
BLOOD (2002)
Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMTP140K into hematopoietic stem cells
M Jansen et al.
CANCER GENE THERAPY (2002)
HIV-1 integration in the human genome favors active genes and local hotspots
ARW Schröder et al.
CELL (2002)
RNA 3′ readthrough of oncoretrovirus and lentivirus:: Implications for vector safety and efficacy
AK Zaiss et al.
JOURNAL OF VIROLOGY (2002)
Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning
A Aiuti et al.
SCIENCE (2002)
Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs
BR Sorrentino
NATURE REVIEWS CANCER (2002)
High-level transduction and gene expression in hematopoietic repopulating cells using a human imunodeficiency virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter
C Demaison et al.
HUMAN GENE THERAPY (2002)
Murine leukemia induced by retroviral gene marking
ZX Li et al.
SCIENCE (2002)
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy
S Hacein-Bey-Abina et al.
NEW ENGLAND JOURNAL OF MEDICINE (2002)
Lentiviral transduction of P140K MGMT into human CD34+ hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro
SP Zielske et al.
MOLECULAR THERAPY (2002)
Protection and in vivo selection of hematopoietic stem cells using temozolomide, O-6-benzylguanine, and an alkyltransferase-expressing retroviral vector
N Sawai et al.
MOLECULAR THERAPY (2001)
MDR1 gene expression in NOD/SCID repopulating cells after retroviral gene transfer under clinically relevant conditions
AJ Schilz et al.
MOLECULAR THERAPY (2000)
Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma
HS Friedman et al.
JOURNAL OF CLINICAL ONCOLOGY (2000)