期刊
HUMAN BRAIN MAPPING
卷 39, 期 12, 页码 4939-4948出版社
WILEY
DOI: 10.1002/hbm.24335
关键词
task evoked functional connectivity; natural vision; spontaneous activity; task-rest interaction
资金
- National Institutes of Health [UL1 TR001108, TL1 TR001107]
- NIH [R01 AG019771, P30 AG010133, R01MH104402]
- National Institute of Mental Health
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [TL1TR001107, UL1TR001108] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH104402] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P30AG010133, R01AG019771] Funding Source: NIH RePORTER
During complex tasks, patterns of functional connectivity differ from those in the resting state. However, what accounts for such differences remains unclear. Brain activity during a task reflects an unknown mixture of spontaneous and task-evoked activities. The difference in functional connectivity between a task state and the resting state may reflect not only task-evoked functional connectivity, but also changes in spontaneously emerging networks. Here, we characterized the differences in apparent functional connectivity between the resting state and when human subjects were watching a naturalistic movie. Such differences were marginally explained by the task-evoked functional connectivity involved in processing the movie content. Instead, they were mostly attributable to changes in spontaneous networks driven by ongoing activity during the task. The execution of the task reduced the correlations in ongoing activity among different cortical networks, especially between the visual and non-visual sensory or motor cortices. Our results suggest that task-evoked activity is not independent from spontaneous activity, and that engaging in a task may suppress spontaneous activity and its inter-regional correlation.
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