期刊
HUMAN BRAIN MAPPING
卷 35, 期 7, 页码 3517-3528出版社
WILEY
DOI: 10.1002/hbm.22418
关键词
functional connectivity; alcohol; anti-correlated networks; simultaneous EEG-fMRI
资金
- National Nature Science Foundation of China [31200857]
- National Key Discipline of Basic Psychology at Southwest University [NSKD11047]
- Humanity and Social Science Youth foundation of Ministry of Education of China [12YJC190015]
- Swiss National Science Foundation [320030_146531]
- Seventh Framework Programme of the European Commission [PCIG12-334039]
- Swiss National Science Foundation (SNF) [320030_146531] Funding Source: Swiss National Science Foundation (SNF)
Functional magnetic imaging (fMRI) studies showed that resting state activity in the healthy brain is organized into multiple large-scale networks encompassing distant regions. A key finding of resting state fMRI studies is the anti-correlation typically observed between the dorsal attention network (DAN) and the default mode network (DMN), whichduring task performanceare activated and deactivated, respectively. Previous studies have suggested that alcohol administration modulates the balance of activation/deactivation in brain networks, as well as it induces significant changes in oscillatory activity measured by electroencephalography (EEG). However, our knowledge of alcohol-induced changes in band-limited EEG power and their potential link with the functional interactions between DAN and DMN is still very limited. Here we address this issue, examining the neuronal effects of alcohol administration during resting state by using simultaneous EEG-fMRI. Our findings show increased EEG power in the theta frequency band (4-8 Hz) after administration of alcohol compared to placebo, which was prominent over the frontal cortex. More interestingly, increased frontal tonic EEG activity in this band was associated with greater anti-correlation between the DAN and the frontal component of the DMN. Furthermore, EEG theta power and DAN-DMN anti-correlation were relatively greater in subjects who reported a feeling of euphoria after alcohol administration, which may result from a diminished inhibition exerted by the prefrontal cortex. Overall, our findings suggest that slow brain rhythms are responsible for dynamic functional interactions between brain networks. They also confirm the applicability and potential usefulness of EEG-fMRI for central nervous system drug research. Hum Brain Mapp 35:3517-3528, 2014. (c) 2013 Wiley Periodicals, Inc.
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