期刊
HUMAN BRAIN MAPPING
卷 34, 期 6, 页码 1306-1318出版社
WILEY
DOI: 10.1002/hbm.21511
关键词
SD rat brain; MRI imaging analysis; SPM; normalization; location; co-registration
资金
- National Basic Research Program of China (973 Program) [2007CB512303, 2011CB707802]
- National Natural Science Foundation of China [30970768]
- Tianjin Natural Science Foundation [08JCZDJC23700]
- National Institute of Mental Health US [ROI MH57899]
- National Institute on Aging, US [9R01AG031581-10, P30 AG19610]
- state of Arizona
This study constructs a rat brain T2-weighted magnetic resonance imaging template including olfactory bulb and a compatible digital atlas. The atlas contains 624 carefully delineated brain structures based on the newest (2005) edition of rat brain atlas by Paxinos and Watson. An automated procedure, as an SPM toolbox, was introduced for spatially normalizing individual rat brains, conducting statistical analysis and visually localizing the results in the Atlas coordinate space. The brain template/atlas and the procedure were evaluated using functional images between rats with the right side middle cerebral artery occlusion (MCAO) and normal controls. The result shows that the brain region with significant signal decline in the MCAO rats was consistent with the occlusion position. Hum Brain Mapp, 2013. (c) 2012 Wiley Periodicals, Inc.
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