期刊
HUMAN BRAIN MAPPING
卷 35, 期 1, 页码 185-198出版社
WILEY
DOI: 10.1002/hbm.22167
关键词
working memory; gray matter; brain activation; deactivation
资金
- Japan Science and Technology Agency (JST)/Research Institute of Science and Technology for society, JST/Core research for Evolutional Science and Technology
The association between functional activation and gray matter (GM) structure has been revealed in clinical studies and studies of aging involving a small number of subjects. The purpose of this study was to investigate the association between functional activation maps and GM structures in young adults who do not show apparent GM atrophy and to investigate in detail the nature of this association using a large number of subjects. We used voxel-by-voxel regression analyses to investigate voxel-by-voxel associations between GM concentration (GMC) and contrast estimate images of brain activity during n-back working memory tasks. Associations were assessed for each voxel after regressing out the effects of age, sex, and mean signal intensity during functional magnetic resonance imaging scanning at each voxel using data from 248 normal, right-handed, young adult subjects. In our study, the concept of the greater the GMC, the greater the task-related activation increase/task-related activation decrease (or the greater the task-related activation change from baseline) was true for a wide range of activated and deactivated areas. However, in some minor regions, the other pattern of the greater the GMC, the smaller the task-related activation increase was observed. The first pattern is often observed at the borders of GM structures. These findings may have to be taken into consideration when group/individual differences in functional activation are investigated. Hum Brain Mapp 35:185-198, 2014. (c) 2012 Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据