期刊
HUMAN BRAIN MAPPING
卷 35, 期 1, 页码 30-37出版社
WILEY
DOI: 10.1002/hbm.22154
关键词
depression; autoimmunity; hippocampus; cornu ammonis; magnetic resonance imaging
资金
- National Institutes of Health [NIH R01 MH59708, R01-HD043323, K01EB013633]
- National Institute on Aging [K01 AG028404]
- European Union [MC FP7-PEOPLE-2010-RG268381]
- Skirball Foundation
- Department of Defense [W81XWH-10-1-0882]
- Cousins Center for Psychoneuroimmunology
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD043323] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [P41EB015922, K01EB013633] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH059708] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [K01AG028404] Funding Source: NIH RePORTER
Depression is very common in multiple sclerosis (MS) but the underlying biological mechanisms are poorly understood. The hippocampus plays a key role in mood regulation and is implicated in the pathogenesis of depression. This study utilizes volumetric and shape analyses of the hippocampus to characterize neuroanatomical correlates of depression in MS. A cross-section of 109 female patients with MS was evaluated. Bilateral hippocampi were segmented from MRI scans (volumetric T-1-weighted, 1 mm(3)) using automated tools. Shape analysis was performed using surface mesh modeling. Depression was assessed using the Center for Epidemiologic Studies-Depression (CES-D) scale. Eighty-three subjects were classified as low depression (CES-D 0-20) versus 26 subjects with high depression (CES-D 21). Right hippocampal volumes (P = 0.04) were smaller in the high depression versus the low depression groups, but there was no significant difference in left hippocampal volumes. Surface rendering analysis revealed that hippocampal shape changes in depressed patients with MS were clustered in the right hippocampus. Significant associations were found between right hippocampal shape and affective symptoms but not vegetative symptoms of depression. Our results suggested that regionally clustered reductions in hippocampal thickness can be detected by automated surface mesh modeling and may be a biological substrate of MS depression in female patients. Hum Brain Mapp 35:30-37, 2014. (c) 2012 Wiley Periodicals, Inc.
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