期刊
HUMAN BRAIN MAPPING
卷 34, 期 12, 页码 3143-3157出版社
WILEY
DOI: 10.1002/hbm.22129
关键词
resting-state fMRI; functional connectivity; intelligence; cognitive practice; ICA-dual regression
资金
- Ministerio de Ciencia e Innovacion, Spain [PSI2010-20364]
- Ministerio de Educacion, Spain [AP2008-00433]
- Universidad Politecnica de Madrid, Spain [RR02/2009]
Neuroimaging studies provide evidence for organized intrinsic activity under task-free conditions. This activity serves functionally relevant brain systems supporting cognition. Here, we analyze changes in resting-state functional connectivity after videogame practice applying a test-retest design. Twenty young females were selected from a group of 100 participants tested on four standardized cognitive ability tests. The practice and control groups were carefully matched on their ability scores. The practice group played during two sessions per week across 4 weeks (16 h total) under strict supervision in the laboratory, showing systematic performance improvements in the game. A group independent component analysis (GICA) applying multisession temporal concatenation on test-retest resting-state fMRI, jointly with a dual-regression approach, was computed. Supporting the main hypothesis, the key finding reveals an increased correlated activity during rest in certain predefined resting state networks (albeit using uncorrected statistics) attributable to practice with the cognitively demanding tasks of the videogame. Observed changes were mainly concentrated on parietofrontal networks involved in heterogeneous cognitive functions. Hum Brain Mapp 34:3143-3157, 2013. (c) 2012 Wiley Periodicals, Inc.
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