期刊
HUMAN BRAIN MAPPING
卷 33, 期 4, 页码 938-957出版社
WILEY
DOI: 10.1002/hbm.21261
关键词
adolescence; face; probability
资金
- European Community [LSHM-CT-2007-037286]
- UK Department of Health NIHR-Biomedical Research Centre Mental Health
- MRC [93558]
- MRC [G0901858] Funding Source: UKRI
- Medical Research Council [G9817803B, G0901858] Funding Source: researchfish
Large-scale magnetic resonance (MR) studies of the human brain offer unique opportunities for identifying genetic and environmental factors shaping the human brain. Here, we describe a dataset collected in the context of a multi-centre study of the adolescent brain, namely the IMAGEN Study. We focus on one of the functional paradigms included in the project to probe the brain network underlying processing of ambiguous and angry faces. Using functional MR (fMRI) data collected in 1,110 adolescents, we constructed probabilistic maps of the neural network engaged consistently while viewing the ambiguous or angry faces; 21 brain regions responding to faces with high probability were identified. We were also able to address several methodological issues, including the minimal sample size yielding a stable location of a test region, namely the fusiform face area (FFA), as well as the effect of acquisition site (eight sites) and scanner (four manufacturers) on the location and magnitude of the fMRI response to faces in the FFA. Finally, we provided a comparison between male and female adolescents in terms of the effect sizes of sex differences in brain response to the ambiguous and angry faces in the 21 regions of interest. Overall, we found a stronger neural response to the ambiguous faces in several cortical regions, including the fusiform face area, in female (vs. male) adolescents, and a slightly stronger response to the angry faces in the amygdala of male (vs. female) adolescents. Hum Brain Mapp, 2012. (c) 2011 Wiley Periodicals, Inc.
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