期刊
HUMAN BRAIN MAPPING
卷 31, 期 5, 页码 786-797出版社
WILEY
DOI: 10.1002/hbm.20905
关键词
mild cognitive impairment; conversion; hippocampal atrophy; medial temporal atrophy; magnetic resonance imaging; imaging biomarker
资金
- NIA [U01 AG10483, K23 AG026803]
- AFAR
- John A. Hartford Foundation
- Atlantic Philanthropies
- Starr Foundation
- Turken foundation [NIA AG16570, NIBIB EB01651, NLM LM05639, NCRR RR019771, NIMH R01 MH071940, NCRR P41 RR013642, NIH U54 RR021813]
We applied the hippocampal radial atrophy mapping technique to the baseline and follow-up magnetic resonance image data of 169 amnestic mild cognitive impairment (MCI) participants in the imaging arm of the Alzheimer's Disease Cooperative Study MCI Donepezil/Vitamin E trial. Sixty percent of the subjects with none to mild hippocampal atrophy rated with the visual medial temporal atrophy rating scale (MTA score < 2) and 33.8% of the subjects with moderate to severe (MTA >= 2) hippocampal atrophy converted to Alzheimer's disease (AD) during 3-year follow-up. MTA >= 2 showed a trend for greater left sided hippocampal atrophy versus MTA < 2 groups at baseline (P-corrected = 0.08). Higher MTA scores were associated with progressive atrophy of the subiculum and the CA1-3 subregions. The MTA < 2 group demonstrated significant bilateral atrophy progression at follow-up (left P-corrected = 0.008; right P-corrected = 0.05). Relative to MTA < 2 nonconverters, MTA < 2 converters showed further involvement of the subiculum and CA1 and additional involvement of CA2-3 at follow-up. Right CA1 atrophy was significantly associated with conversion to dementia (for 1 mm greater right CA1 radial distance subjects had 50% reduced hazard for conversion). Greater CA1 and subicular atrophy can be demonstrated early and is predictive of future conversion to AD, whereas CA2-3 involvement becomes more evident as the disease progresses. Hunt Brain Mapp 31:786-797, 2010. (C) 2010 Wiley-Liss, Inc.
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