期刊
HUMAN BRAIN MAPPING
卷 31, 期 9, 页码 1359-1379出版社
WILEY
DOI: 10.1002/hbm.20940
关键词
medial temporal lobe; entorhinal cortex, parahippocampal gyros, perirhinal cortex, fusiform gyrus, Tau pathology, calcium-binding proteins, collateral sulcus, aging brain, cortical mapping
资金
- NINDS [NS 14944]
Despite rapidly increasing Interests in specific contributions of different components of human medial temporal lobe (MTL) to memory and memory impairments in normal aging and in many abnormal conditions such as Alzheimei's disease and Pick's disease, few modern neuroanatomical studies are available about the borders, extent, and topography of human perirhinal areas 35 and 36, which are important components of the MTL, memory system By a combined use of several cellular, neurochemical, and pathological markers, which mainly include neuronal nuclear antigen, calcium-binding proteins (parvalbumin and calbindin-D28k), nonphosphorylated neurofilament protein (SMI-32), Wisteria floribunda agglutinin, and abnormally phosphorylated tau (AT8), this study has revealed that the borders of human perirhinal areas 35 and 36 are significantly different from those defined with conventional Nissl staining. In general, areas 35 and 36 occupy the ventromedial temporopolar and rhinal sulcal regions, the collateral sulcal region, and the anterior two-thirds of fusiform gyrus or occipitotemporal gyrus Furthermore, the precise borders, extent, and topography of human areas 35 and 36 and adjoining entorhinal cortex were marked at different anteroposterior levels of the MTL with reference to variations of rhinal and collateral sulci and other useful landmarks. These findings would provide reliable neuroanatomical base for the great and yet rapidly increasing number of neuroimaging studies of the human MTI, structures in healthy and many abnormal conditions Hum Brain Mapp 31 1359-1379, 2010 (C) 2010 Whey-Use. Inc
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