期刊
HUMAN BRAIN MAPPING
卷 32, 期 7, 页码 1109-1124出版社
WILEY
DOI: 10.1002/hbm.21095
关键词
topology correction; spherical harmonics; surface reconstruction; topological defects; noise; self-intersections; MRI
资金
- German Bundesministerium fur Bildung und Forschung [BMBF 01EV0709, BMBF 01GW0740]
- NIH [EB008432, EB008281, EB007813, HD050735]
Surface reconstruction methods allow advanced analysis of structural and functional brain data beyond what can be achieved using volumetric images alone. Automated generation of cortical surface meshes from 3D brain MRI often leads to topological defects and geometrical artifacts that must be corrected to permit subsequent analysis. Here, we propose a novel method to repair topological defects using a surface reconstruction that relies on spherical harmonics. First, during reparameterization of the surface using a tiled platonic solid, the original MRI intensity values are used as a basis to select either a fill'' or cut'' operation for each topological defect. We modify the spherical map of the uncorrected brain surface mesh, such that certain triangles are favored while searching for the bounding triangle during reparameterization. Then, a low-pass filtered alternative reconstruction based on spherical harmonics is patched into the reconstructed surface in areas that previously contained defects. Self-intersections are repaired using a local smoothing algorithm that limits the number of affected points to less than 0.1% of the total, and as a last step, all modified points are adjusted based on the T1 intensity. We found that the corrected reconstructions have reduced distance error metrics compared with a gold standard'' surface created by averaging 12 scans of the same brain. Ninety-three percent of the topological defects in a set of 10 scans of control subjects were accurately corrected. The entire process takes 6-8 min of computation time. Further improvements are discussed, especially regarding the use of the T1-weighted image to make corrections. Hum Brain Mapp 32: 1109-1124, 2011. (C) 2010 Wiley-Liss, Inc.
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